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"LITTLE" Lipoprotein (a) is a "BIG" deal!

Feb 04, 2025

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“๐‹๐ˆ๐“๐“๐‹๐„” ๐‹๐ข๐ฉ๐จ๐ฉ๐ซ๐จ๐ญ๐ž๐ข๐ง (๐š) ๐ข๐ฌ ๐š “๐๐ˆ๐†” ๐๐ž๐š๐ฅ! ๐ˆ๐ ๐ง๐จ๐ซ๐ข๐ง๐  ๐ข๐ญ ๐œ๐จ๐ฎ๐ฅ๐ ๐›๐ž ๐š ๐ฌ๐ž๐ซ๐ข๐จ๐ฎ๐ฌ ๐ฆ๐ข๐ฌ๐ญ๐š๐ค๐ž.

Have you considered why some young adults with “healthy” cholesterol and LDL levels still suffer heart attacks? The answer is clear: the often-overlooked lipid particles pose hidden dangers. Let’s explore one such lipid particle that could increase our risk of heart attack.

While LDL cholesterol often takes the spotlight, Lipoprotein (a) (Lp(a)) represents a crucial independent risk factor for Atherosclerotic Cardiovascular Disease (ASCVD). Lp(a) is two and a half times more atherogenic than LDL, and it drives inflammation and clotting, aggressively promoting plaque formation in our arteries.

Genetically inherited in an autosomal dominant manner, elevated Lp(a) levels can affect up to 20% of those in India.

Who should be tested?

Therefore, leading cardiovascular organizations advocate for testing Lp(a) levels in individuals with:

1.โ  โ A family history of premature ASCVD

2.โ  โ Unexplained or recurrent ASCVD

3.โ  โ A history of ischemic stroke

4.โ  โ Family members with elevated Lp(a)

๐–๐ก๐š๐ญ ๐ฌ๐ก๐จ๐ฎ๐ฅ๐ ๐ฐ๐ž ๐๐จ ๐š๐›๐จ๐ฎ๐ญ ๐‹๐ข๐ฉ๐จ๐ฉ๐ซ๐จ๐ญ๐ž๐ข๐ง (๐š)?

1.โ  โ Embrace ๐ฎ๐ง๐ข๐ฏ๐ž๐ซ๐ฌ๐š๐ฅ ๐ฌ๐œ๐ซ๐ž๐ž๐ง๐ข๐ง๐  for high-risk individuals.

2.โ  โ Engage in ๐š๐ ๐ ๐ซ๐ž๐ฌ๐ฌ๐ข๐ฏ๐ž ๐ฆ๐š๐ง๐š๐ ๐ž๐ฆ๐ž๐ง๐ญ of traditional cardiovascular risk factors.

3.โ  โ Adopt ๐ก๐ž๐š๐ฅ๐ญ๐ก๐ฒ ๐ฅ๐ข๐Ÿ๐ž๐ฌ๐ญ๐ฒ๐ฅ๐ž ๐œ๐ก๐š๐ง๐ ๐ž๐ฌ through the “DASH” program:

• ๐ƒ- Diet: Commit to a whole-food, plant-based diet

• ๐€- Aactive living: Cultivate regular yoga, meditation, Pranayama or exercise and daily walking,

• ๐’- stress management: optimize stress, sleep, social connections, and spiritual health

• ๐‡- habit changes: Dedicate yourself to smoking cessation and alcohol avoidance

4.โ  โ Consider ๐ฅ๐จ๐ฐ-๐๐จ๐ฌ๐ž ๐€๐ฌ๐ฉ๐ข๐ซ๐ข๐ง for prevention.

5.โ  โ Utilize ๐๐‚๐’๐Š-๐Ÿ— ๐ข๐ง๐ก๐ข๐›๐ข๐ญ๐จ๐ซ๐ฌ like Inclisiran and look forward to innovative RNA-based therapies such as Pelacarsen and Olpasiran shortly

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"LITTLE" Lipoprotein (a) is a "BIG" deal!